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Dimethylformamide → N-(2-phenylethyl)-4-[4-(trifluoromethyl)phenyl]-1,3-thiazole-2-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | 2-Bromo-4'-(trifluoromethyl)acetophenone | HCID 321979 | — |
| 反応物 | (2-Phenylethyl)thiourea | HCID 735845 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | N-(2-phenylethyl)-4-[4-(trifluoromethyl)phenyl]-1,3-thiazole-2-amine | HCID 23143279 | 74.7% |
反応手順
A mixture of 2-bromo-1-[4-(trifluoromethyl)phenyl]-ethanone (5.34 g), N-(2-phenylethyl)thiourea (3.60 g) and N,N-dimethylformamide (20 mL) was stirred at room temperature for 1 hr. The reaction mixture was poured into water and extracted with ethyl acetate. The ethyl acetate layer was dried over anhydrous magnesium sulfate and concentrated to give the title compound (5.20 g, yield 74%) as colorless crystals.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07585880B2 |
| 出典データセット | uspto-grants-2009_09 |
| ORD ID | ord-ba9edc3cfea846ac9d61fddbdf795fc6 |
| 出典メモ | uspto-grants-2009_09 |