Propylamine → HCID 23143269、化合物

HRID 732179ノート

反応式

HRID 732179 の反応式
Cl[C:2]1[O:3][C:4]([CH3:13])=[C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[N:6]=1.[CH2:14]([NH2:17])[CH2:15][CH3:16]>C(O)C>[CH3:13][C:4]1[O:3][C:2]([NH:17][CH2:14][CH2:15][CH3:16])=[N:6][C:5]=1[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

参加物

4

反応物 2

HCID 7852PropylamineHCID 23143330HCID 23143330、化合物

生成物 1

HCID 23143269HCID 23143269、化合物収率 52%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
110 °C

実験手順

To a solution of 2-chloro-5-methyl-4-phenyl-1,3-oxazole (1.46 g, 7.56 mmol) in ethanol (15 mL) was added propylamine (5 mL), and the mixture was stirred in a sealed tube at 110° C. for 8 hr. The reaction mixture was concentrated and water was added. The mixture was extracted with ethyl acetate, washed with saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate=2:1) to give the title compound (850 mg, yield 52%) as a yellow powder.

後処理

  1. concentrationThe reaction mixture was concentrated
  2. additionwater was added
  3. extractionThe mixture was extracted with ethyl acetate
  4. washwashed with saturated brine
  5. dry with materialdried over anhydrous magnesium sulfate
  6. concentrationconcentrated under reduced pressure
  7. customThe residue was purified by silica gel column chromatography (hexane/ethyl acetate=2:1)

出典と根拠

ORDレコード
ord-f62c279acaac4d96a49ec6c22f8f7fd4
出典データセット
uspto-grants-2009_09
特許番号
US07585880B2

反応ノート

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