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Water → N-(3-Methylbutyl)-4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | 2-Bromo-4'-(trifluoromethyl)acetophenone | HCID 321979 | — |
| 反応物 | Sodium Acetate | HCID 517045 | — |
| 反応物 | (3-Methyl-butyl)-thiourea | HCID 2459097 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | N-(3-Methylbutyl)-4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-amine | HCID 23143261 | 74% |
反応手順
A solution of N-(3-methylbutyl)thiourea (3.00 g, 20.5 mmol), 2-bromo-1-[4-(trifluoromethyl)phenyl]ethanone (5.45 g, 20.5 mmol) and sodium acetate (2.19 g, 26.7 mmol) in ethanol (50 mL) was stirred at 90° C. for 4 hr. The reaction mixture was poured into water and extracted with ethyl acetate. The extract was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The obtained solid was recrystallized from dichloromethane-hexane to give the title compound (1.76 g, yield 74%) as pale-yellow crystals.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07585880B2 |
| 出典データセット | uspto-grants-2009_09 |
| ORD ID | ord-024d07fd5d9f4ba3ab58868d34764847 |
| 出典メモ | uspto-grants-2009_09 |