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Benzenepropanoic acid, 4-hydroxy-, methyl ester → Methyl 3-{4-[(4-{[(4-phenyl-1,3-thiazol-2-yl)(2-pyridin-2-ylethyl)amino]methyl}benzyl)oxy]phenyl}propanoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzenepropanoic acid, 4-hydroxy-, methyl ester | HCID 79706 | — |
| 反応物 | (4-([(4-Phenyl-1,3-thiazol-2-yl)(2-pyridin-2-ylethyl)amino]methyl}phenyl)methanol | HCID 23143295 | — |
| 生成物 | Methyl 3-{4-[(4-{[(4-phenyl-1,3-thiazol-2-yl)(2-pyridin-2-ylethyl)amino]methyl}benzyl)oxy]phenyl}propanoate | HCID 23143288 | 57% |
反応手順
The title compound was synthesized in the same manner as in Example 8 from (4-{[(4-phenyl-1,3-thiazol-2-yl)(2-pyridin-2-ylethyl)amino]methyl}phenyl)methanol and methyl 3-(4-hydroxyphenyl)propanoate by Mitsunobu reaction (yield 57%). Yellow oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07585880B2 |
| 出典データセット | uspto-grants-2009_09 |
| ORD ID | ord-0eb6a71bc6ad415ea62f9cdb7fbd562b |
| 出典メモ | uspto-grants-2009_09 |