化工社化工社 化学情報印刷レポート · 研究参考用
Boron trifluoride → 4-(5-Isopropyl-2-Methyl-1,3-Thiazol-4-Yl)-Phenol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Boron trifluoride | HCID 6356 | — |
| 反応物 | Sodium Cyanide | HCID 8929 | — |
| 反応物 | Bromic acid | HCID 24445 | — |
| 反応物 | 5-Isopropyl-4-(4-Methoxy-Phenyl)-2-Methyl-1,3-Thiazole | HCID 57838363 | — |
| 触媒 | Tetrabutylammonium Iodide | HCID 67553 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 溶媒 | Dimethyl Sulfoxide | HCID 679 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 4-(5-Isopropyl-2-Methyl-1,3-Thiazol-4-Yl)-Phenol | HCID 16202444 | — |
反応手順
In the fourth step, the compound (5) prepared in the third step is reacted with bromic acid and acetic acid, sodium cyanide and dimethylsulfoxide, or tetrabutylammonium iodide and boron trifluoride.diethylether, to afford 4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl)-phenol (6). Conventionally, ethanethiol is used, whereby offensive odors occur and reagent handling is difficult to the extent of being unsuitable for use in mass production. However, in the present invention, the use of the compound (5) and the above materials reacting therewith, in particular, bromic acid and acetic acid result in decreased offensive odors, low price, simple reagent handling and a drastically increased preparation yield (yield: 84%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07585979B2 |
| 出典データセット | uspto-grants-2009_09 |
| ORD ID | ord-125362ffe0174e0bb4b5bb8def022a0f |
| 出典メモ | uspto-grants-2009_09 |