Bromine → 2-bromo-1-(4-Methoxy-Phenyl)-3-Methyl-Butan-1-One

HRID 732242ノート

反応式

HRID 732242 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9](=[O:14])[CH2:10][CH:11]([CH3:13])[CH3:12])=[CH:5][CH:4]=1.[Br:15]Br>C(OC(=O)C)C>[Br:15][CH:10]([CH:11]([CH3:12])[CH3:13])[C:9]([C:6]1[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=1)=[O:14]

参加物

4

反応物 2

HCID 24408BromineHCID 127577691-(4-Methoxyphenyl)-3-methylbutan-1-one

生成物 1

HCID 578383622-bromo-1-(4-Methoxy-Phenyl)-3-Methyl-Butan-1-One収率 96%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

While 56.9 g of 1-(4-methoxy-phenyl)-3-methyl-butan-1-one (3) prepared in Example 1 were added to 200 ml of ethylacetate and stirred, 18.2 ml of bromine were added at room temperature and stirring was continued at the same temperature for 1 hr. After the reaction was completed, the resultant reaction mixture was washed with brine and water, in that order, after which the ethylacetate layer was dried over anhydrous magnesium sulfate and then concentrated under reduced pressure, thus obtaining 77.0 g (yield: 96.0%) of a title compound as light yellow liquid.

後処理

  1. stirringstirring
  2. customthe resultant reaction mixture
  3. washwas washed with brine and water, in that order
  4. dry with materialafter which the ethylacetate layer was dried over anhydrous magnesium sulfate
  5. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-14fbaff9b5c843eab796a9252eabdb5a
出典データセット
uspto-grants-2009_09
特許番号
US07585979B2

反応ノート

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