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Hydrochloric Acid → 4-Chlorobutane-1-sulphonyl chloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 1-Butanol, 4-chloro-, 1-acetate | HCID 23399 | — |
| 反応物 | Sodium Sulfite | HCID 24437 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 4-Chlorobutane-1-sulphonyl chloride | HCID 74212 | — |
反応手順
Add anhydrous sodium sulfite (16.8 g, 130 mmol) to a solution of 4-chlorobutyl acetate (20.0 g, 133 mmol) in water (50 mL) and reflux the mixture for 20 h. Cool to room temperature and add concentrated HCl (19.0 mL) and reflux for 1 h. Cool the mixture to room temperature, neutralize to about pH=7. Concentrate to about one half the volume, filter away the sodium chloride. Concentrate and dry to give the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07585885B2 |
| 出典データセット | uspto-grants-2009_09 |
| ORD ID | ord-d56b9ba0d8e84946ae969baed6e81415 |
| 出典メモ | uspto-grants-2009_09 |