Ethanol → Ethanol water glycerin glycerol monooleate

HRID 7327

反応式

HRID 7327 の反応式
[CH2:1]([OH:3])[CH3:2].[C:4]([O:23][CH2:24][CH:25]([CH2:27][OH:28])[OH:26])(=[O:22])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11]/[CH:12]=[CH:13]\[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21]>O.OCC(CO)O>[CH2:1]([OH:3])[CH3:2].[OH2:22].[OH:23][CH2:24][CH:25]([CH2:27][OH:28])[OH:26].[C:4]([O:23][CH2:24][CH:25]([CH2:27][OH:28])[OH:26])(=[O:22])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11]/[CH:12]=[CH:13]\[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21]

参加物

5

反応物 2

HCID 702EthanolHCID 5283468Glyceryl Monooleate

生成物 1

HCID 131716747Ethanol water glycerin glycerol monooleate

試薬・触媒・溶媒 2

HCID 753Glycerol溶媒HCID 962Water溶媒

実験手順

95% ethanol (USP) was diluted with water (USP), glycerin (USP), and glycerol monooleate (Eastman Chemical, Kingsport N.Y.) to provide a final solution at ethanol/water/glycerin/glycerol monooleate percent ratios of 35/59/5/1, respectively. Oxybutynin free base was then dissolved into the above solution to a concentration of 10 mg/gram. The resultant solution was then gelled with 1% hydroxypropyl cellulose (Aqualon, Wilmington, Del.) to provide a final oxybutynin gel. One to two grams of the above gel is applied topically to approximately 200 cm2 surface area on the chest, torso, and or arms to provide topical administration of oxybutynin.

出典と根拠

ORDレコード
ord-b86fd53c2c1347ee8ef00fd260228086
出典データセット
uspto-grants-2006_08
特許番号
US07087241B2

関連ノート

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