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4-Iodophenol → 5-[(4-Iodophenoxy)methyl]bicyclo[2.2.1]hept-2-ene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Iodophenol | HCID 10894 | — |
| 反応物 | Triphenylphosphine | HCID 11776 | — |
| 反応物 | Bicyclo(2.2.1)hept-5-ene-2-methanol | HCID 78946 | — |
| 反応物 | Diethyl azodicarboxylate | HCID 5462977 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 5-[(4-Iodophenoxy)methyl]bicyclo[2.2.1]hept-2-ene | HCID 21989300 | 97% |
反応手順
Diethylazodicarboxylate (8.7 g) was added dropwise to a solution of 5-norbornene-2-methanol (6.2 g, 0.05 mol), 4-iodophenol (11.0 g, 0.05 mol) and triphenylphosphine (13.1 g, 0.05 mol) in 100 mL of anhydrous tetrahydrofuran. After completion of the addition, the resulting solution was stirred for 18 h at room temperature. The solvent was removed under reduced pressure and the oily residue was extracted three times with hot hexane. Combined hexane extracts were evaporated under reduced pressure to give 8 (15.0 g, 97%) as a colorless oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07087267B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-fe246bcbccfc45eab97f443429b20fe3 |
| 出典メモ | uspto-grants-2006_08 |