Ammonia → ((1S,2S)-2-(4-bromophenyl)cyclopropyl)methanol

関与物質

役割	名称	HCID	仕込み量
反応物	Ammonia	HCID 222	—
反応物	3-Phenylprop-2-En-1-Ol	HCID 308	—
反応物	(2E)-3-(4-bromophenyl)prop-2-en-1-ol	HCID 11183465	—
生成物	((1S,2S)-2-(4-bromophenyl)cyclopropyl)methanol	HCID 57515373	—

反応手順

The title compound was prepared by the method of A. B. Charette and H. Lebel (Organic Synthesis, 1998, 76, 86-96) substituting trans-3-(4-bromophenyl) prop-2-en-1-ol (the product of Example 1A) for 3-phenyl-prop-2-en-1-ol. 1H NMR (300 MHz, CDCl3): δ 0.92-1.0 (m, 2H), 1.45-1.48 (m, 2H), 1.76-1.85 (m, 1H), 3.61 (d, J=7.5 Hz, 2H), 6.95 (d, J=9 Hz, 2H), 7.37 (d, J=9 Hz, 2H). MS (DCl—NH3) m/z 228 (M+H)+.

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US08829041B2
出典データセット	uspto-grants-2014_09
ORD ID	ord-9ace77be25d64f70be9369bb4b5998d0
出典メモ	uspto-grants-2014_09