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N,N-Dimethylaniline → 2,4-Dibromophenyl 4-(prop-2-ynyl)piperidine-1-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N,N-Dimethylaniline | HCID 949 | — |
| 反応物 | Tetrahydrofuran | HCID 8028 | — |
| 反応物 | 2,4-Dibromophenol | HCID 12005 | — |
| 反応物 | Triphosgene | HCID 94429 | — |
| 生成物 | 2,4-Dibromophenyl 4-(prop-2-ynyl)piperidine-1-carboxylate | HCID 57838912 | — |
反応手順
2,4-Dibromophenol (7.45 g, 29.6 mmol) was added as a solution in THF and dimethylaniline to a mixture of triphosgene (2.849 g, 9.6 mmol) in THF according to general procedure 3. Yield=6.09 g, 68%. m/z MH+=402.22. HPLC rt=12.49 min.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07589076B2 |
| 出典データセット | uspto-grants-2009_09 |
| ORD ID | ord-c035ca37c20646abba2c8df2711900b0 |
| 出典メモ | uspto-grants-2009_09 |