反応式
O1[C:5]2([CH2:10][CH2:9][CH:8]([CH2:11][N:12]([CH3:14])[CH3:13])[CH2:7][CH2:6]2)[O:4]CC1.Cl>O>[CH3:14][N:12]([CH2:11][CH:8]1[CH2:9][CH2:10][C:5](=[O:4])[CH2:6][CH2:7]1)[CH3:13]参加物
4
実験手順
The crude product of the corresponding [(1,4-dioxaspiro[4.5]dec-8-yl)-methyl]-dimethylamine (88 mmol) was dissolved in water (40 ml), combined with conc. hydrochloric acid (59 ml) and stirred for 20 h at RT. The reaction mixture was extracted with diethyl ether (2×100 ml), the aqueous phase was alkalized with 5N NaOH with ice cooling, extracted with dichloromethane (3×100 ml), dried and evaporated. The products were obtained as white solids or oils.
後処理
- extractionThe reaction mixture was extracted with diethyl ether (2×100 ml)
- extractionextracted with dichloromethane (3×100 ml)
- customdried
- customevaporated
- customThe products were obtained as white solids or oils
出典と根拠
- ORDレコード
- ord-aaa75d598a3040ff8b5913486959acfe
- 出典データセット
- uspto-grants-2009_09
- 特許番号
- US07589113B2
関連ノート
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