化工社化工社 化学情報印刷レポート · 研究参考用
1-Butanol → 4-Bromo-1-butoxy-2-fluorobenzene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Butanol | HCID 263 | — |
| 反応物 | Triphenylphosphine | HCID 11776 | — |
| 反応物 | Diisopropyl diazene-1,2-dicarboxylate | HCID 75555 | — |
| 反応物 | 4-Bromo-2-fluorophenol | HCID 2724981 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 4-Bromo-1-butoxy-2-fluorobenzene | HCID 12067445 | 95.6% |
反応手順
0.315 mol of each of 4-bromo-2-fluorophenol (1), 1-butanol and triphenylphosphine were dissolved in 1000 ml of tetrahydrofuran, and 0.315 mol of diisopropyl azodicarboxylate was added dropwise at about 20° C. After the mixture had been stirred overnight, the solvent was removed by distillation in a rotary evaporator, and the residue was subjected to conventional work-up, giving the compound (2) in a yield of 95.6% of theory.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07087272B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-d7098213ef994e7f871969c33d7d6733 |
| 出典メモ | uspto-grants-2006_08 |