関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydroxylamine | HCID 787 | — |
| 反応物 | Water | HCID 962 | — |
| 反応物 | 6-Fluoroindole-3-carboxaldehyde | HCID 262903 | — |
| 反応物 | Sodium Formate | HCID 2723810 | — |
| 溶媒 | Formic Acid | HCID 284 | — |
| 生成物 | 6-Fluoro-1H-indole-3-carbonitrile | HCID 53418730 | 59.9% |
反応手順
To a solution of 6-fluoro-1H-indole-3-carbaldehyde (0.97 g) in 90% formic acid (25 mL) were added hydroxylamine (0.65 g) and sodium formate (0.81 g), and this mixture was stirred at 100° C. for 3 hours. After cooling to ambient temperature, water was added to this reaction mixture and the precipitated solid was collected by filtration, and washed with water, dried to give the title compound (0.57 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08829040B2 |
|---|
| 出典データセット | uspto-grants-2014_09 |
|---|
| ORD ID | ord-111bd519c84a4f52ada23e687209d777 |
|---|
| 出典メモ | uspto-grants-2014_09 |
|---|
