HCID 22025443、化合物 → HCID 17966419、化合物
反応式
[F:1][C:2]([F:20])([F:19])[CH2:3][N:4]1[C:12](=[O:13])[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([C:14]([F:17])([F:16])[F:15])[CH:10]=2)[C:5]1=[O:18]>O>[OH:13][CH:12]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([C:14]([F:16])([F:17])[F:15])[CH:10]=2)[C:5](=[O:18])[N:4]1[CH2:3][C:2]([F:19])([F:1])[F:20]参加物
3
反応条件
- 温度
- 0 °C
実験手順
5.5 g of 2-(2,2,2-trifluoro-ethyl)-5-trifluoromethyl-isoindole-1,3-dione were dissolved using 150 ml MeOH(anhydrous) and 1.0 g of KBH4 added at ambient temperature. The mixture was left at ambient temperature for 16 h, cooled to 0° C. and poured into 100 ml of water at 0° C. The methanol was removed in vacuo. The aqueous layer was extracted three times using 100 ml of CH2Cl2 each. The organic layer was dried over MgSO4 and the solvent was removed in vacuo to yield 4.2 g of a viscous oil (Rf(DIP)=0.37, MS (DCI): 300 (M+1)+).