Formamide → 4-Chloro-phthalimide
反応式
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=O)[O:8][C:6](=[O:7])[C:5]2=[CH:11][CH:12]=1.O.C([NH2:16])=O>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[O:8])[NH:16][C:6](=[O:7])[C:5]2=[CH:11][CH:12]=1参加物
4
反応条件
- 温度
- 20 °C
実験手順
A solution of 10.0 g of 4-chlorophthalic anhydride in 24.6 g of formamide is heated at a temperature in the region of 120° C. with stirring for 3 hours and is then cooled to a temperature in the region of 20° C. and poured into 100 cm3 of water. After stirring for 30 minutes, the mixture is filtered and the precipitate is then dried under vacuum at a temperature in the region of 60° C. 10.4 g of 4-chlorophthalimide are thus obtained in the form of a solid melting at 171° C. Rf=0.07 (thin layer chromatography on silica gel, eluent: dichloromethane).
後処理
- stirringAfter stirring for 30 minutes
- filtrationthe mixture is filtered
- customthe precipitate is then dried under vacuum at a temperature in the region of 60° C
出典と根拠
- ORDレコード
- ord-e76a3d7582734eb9a8ba17749f6bed4d
- 出典データセット
- uspto-grants-2009_09
- 特許番号
- US07589117B2
反応ノート
読み込み中…