関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Cesium carbonate | HCID 10796 | — |
| 反応物 | Benzoic acid, 4-fluoro-, ethyl ester | HCID 67976 | — |
| 反応物 | 6-Nitro-1H-indole | HCID 78502 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 4-(6-Nitroindol-1-yl)benzoic acid ethyl ester | HCID 58437219 | 66.9% |
反応手順
To a solution of 6-nitro-1H-indole (0.5 g) in N,N-dimethylformamide (10 mL) were added cesium carbonate (1.2 g) and 4-fluoro benzoic acid ethyl ester (0.62 g), and this mixture was stirred at 75° C. overnight. This reaction mixture was poured into water and the precipitated solid was collected by filtration, and washed with water and n-hexane, dried under reduced pressure to give the title compound (0.64 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08829040B2 |
|---|
| 出典データセット | uspto-grants-2014_09 |
|---|
| ORD ID | ord-69ba6b56a72b4875bded66dda5205304 |
|---|
| 出典メモ | uspto-grants-2014_09 |
|---|
