Hydrochloric Acid → (4-Methoxy-5-methyl-2-nitrophenyl)acetonitrile
反応式
COC(=O)[CH:4]([C:17]#[N:18])[C:5]1[CH:10]=[C:9]([CH3:11])[C:8]([O:12][CH3:13])=[CH:7][C:6]=1[N+:14]([O-:16])=[O:15].Cl>CO>[CH3:13][O:12][C:8]1[C:9]([CH3:11])=[CH:10][C:5]([CH2:4][C:17]#[N:18])=[C:6]([N+:14]([O-:16])=[O:15])[CH:7]=1参加物
4
実験手順
To a solution of cyano-(4-methoxy-5-methyl-2-nitrophenyl)acetic acid methyl ester in methanol (1.7 mL) was added 6 mol/L hydrochloric acid (1.7 mL), and this mixture was heated under reflux for 9 hours. After cooling to ambient temperature, this organic solvent was removed under reduced pressure and resulting mixture was extracted with ethyl acetate. The residue was purified by column chromatography on silica gel (eluent: n-hexane/ethyl acetate) to give the title compound (0.25 g).
後処理
- temperaturethis mixture was heated
- temperatureunder reflux for 9 hours
- customthis organic solvent was removed under reduced pressure
- customresulting mixture
- extractionwas extracted with ethyl acetate
- customThe residue was purified by column chromatography on silica gel (eluent: n-hexane/ethyl acetate)
出典と根拠
- ORDレコード
- ord-56ec05281f9c44abacc11222ab97db95
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- US08829040B2
反応ノート
読み込み中…