Potassium Carbonate → 9-(8-aza-bicyclo[3.2.1]oct-3-ylidene)-5-methoxy-9H-xanthene-3-carboxylic acid diethylamide
反応式
[CH2:1]([N:3]([CH2:36][CH3:37])[C:4]([C:6]1[CH:7]=[CH:8][C:9]2[C:10](=[C:22]3[CH2:28][CH:27]4[N:29](C(=O)C(F)(F)F)[CH:24]([CH2:25][CH2:26]4)[CH2:23]3)[C:11]3[C:16]([O:17][C:18]=2[CH:19]=1)=[C:15]([O:20][CH3:21])[CH:14]=[CH:13][CH:12]=3)=[O:5])[CH3:2].C(=O)([O-])[O-].[K+].[K+]>CO>[CH2:36]([N:3]([CH2:1][CH3:2])[C:4]([C:6]1[CH:7]=[CH:8][C:9]2[C:10](=[C:22]3[CH2:23][CH:24]4[NH:29][CH:27]([CH2:26][CH2:25]4)[CH2:28]3)[C:11]3[C:16]([O:17][C:18]=2[CH:19]=1)=[C:15]([O:20][CH3:21])[CH:14]=[CH:13][CH:12]=3)=[O:5])[CH3:37]参加物
4
反応物 2
生成物 1
試薬・触媒・溶媒 1
実験手順
A mixture of 5-methoxy-9-[8-(2,2,2-trifluoro-acetyl)-8-aza-bicyclo[3.2.1]-oct-3ylidene]-9H-xanthene-3-carboxylic acid diethylamide, 5c (3.2g, 6.22 mmol) and potassium carbonate (1.89 g, 13.7 mmol) in methanol (50 mL) was stirred at rt overnight. The mixture was evaporated, and partitioned between methylene chloride (100 mL) and water (100 mL). The organic layer was separated, dried over sodium sulfate, filtered, and evaporated, yielding 2.72 g of 9-(8-aza-bicyclo[3.2.1]oct-3-ylidene)-5-methoxy-9H-xanthene-3-carboxylic acid diethylamide, 6c. MS m/z=419.0 (MH+).