関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 1-Bromo-4-iodobenzene | HCID 11522 | — |
| 反応物 | Sodium metaborate | HCID 145326 | — |
| 反応物 | B-(4-Ethoxy-2,3-difluorophenyl)boronic acid | HCID 15135235 | — |
| 反応物 | Hydrazinium hydrochloride | HCID 21989311 | — |
| 触媒 | HCID 178418476 | HCID 178418476 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 1-Bromo-2',3'-difluoro-4'-ethoxybiphenyl | HCID 21989312 | — |
反応手順
0.450 mol of sodium metaborate are introduced into 240 ml of water. 0.012 mol of bis(triphenylphosphine)palladium(II) chloride, 0.6 mol of 4-bromo-1-iodobenzene (11) and 0.012 mol of hydrazinium hydrochloride are added, and the mixture is stirred at about 20° C. for 5 minutes. 0.6 mol of 2,3-difluoro-4-ethoxyphenylboronic acid (12) dissolved in 600 ml of tetrahydrofuran are then added, and the mixture is refluxed for 4 hours, giving the compound of the formula 13.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07087272B2 |
|---|
| 出典データセット | uspto-grants-2006_08 |
|---|
| ORD ID | ord-eca79e3229d14634afded7b73fa277ff |
|---|
| 出典メモ | uspto-grants-2006_08 |
|---|
