Acetic Acid → Dimethyl-(6-trifluoromethyl-1H-indol-5-yl)amine

HRID 73349ノート

反応式

HRID 73349 の反応式
[CH3:1][N:2]([CH3:19])[C:3]1[C:4]([C:15]([F:18])([F:17])[F:16])=[CH:5][C:6]([N+:12]([O-])=O)=[C:7]([CH2:9][C:10]#N)[CH:8]=1.C(O)C.C(O)(=O)C>[C].[Pd].O>[CH3:1][N:2]([CH3:19])[C:3]1[CH:8]=[C:7]2[C:6](=[CH:5][C:4]=1[C:15]([F:18])([F:17])[F:16])[NH:12][CH:10]=[CH:9]2

参加物

6

反応物 3

HCID 176Acetic AcidHCID 702EthanolHCID 58437521(5-Dimethylamino-2-nitro-4-trifluoromethylphenyl)acetonitrile

生成物 1

HCID 58437283Dimethyl-(6-trifluoromethyl-1H-indol-5-yl)amine収率 119.7%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 962Water溶媒

反応条件

温度
35 °C

実験手順

To a solution of (5-dimethylamino-2-nitro-4-trifluoromethylphenyl)acetonitrile (0.058 g) in a mixed solvent of ethanol (1 mL), acetic acid (0.1 mL) and water (0.1 mL) was added palladium-carbon powder (0.0058 g), and this mixture was stirred at 35° C. for 16 hours. The insoluble material was removed by filtration and the filtrate was concentrated under reduced pressure to give the title compound (0.058 g).

後処理

  1. customThe insoluble material was removed by filtration
  2. concentrationthe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-7f6d2e868f7e4143bf413ee27e8a8cc8
出典データセット
uspto-grants-2014_09
特許番号
US08829040B2

反応ノート

読み込み中…