4-[2-(4-Butylphenyl)ethynyl]benzaldehyde → Methyl {4-[({4-[(4-butylphenyl)ethynyl]benzyl}amino)methyl]phenoxy}acetate

HRID 733571

反応式

HRID 733571 の反応式
C(O)(=O)C.[NH2:5][CH2:6][C:7]1[CH:18]=[CH:17][C:10]([O:11][CH2:12][C:13]([O:15][CH3:16])=[O:14])=[CH:9][CH:8]=1.[CH2:19]([C:23]1[CH:28]=[CH:27][C:26]([C:29]#[C:30][C:31]2[CH:38]=[CH:37][C:34]([CH:35]=O)=[CH:33][CH:32]=2)=[CH:25][CH:24]=1)[CH2:20][CH2:21][CH3:22]>>[CH2:19]([C:23]1[CH:28]=[CH:27][C:26]([C:29]#[C:30][C:31]2[CH:38]=[CH:37][C:34]([CH2:35][NH:5][CH2:6][C:7]3[CH:18]=[CH:17][C:10]([O:11][CH2:12][C:13]([O:15][CH3:16])=[O:14])=[CH:9][CH:8]=3)=[CH:33][CH:32]=2)=[CH:25][CH:24]=1)[CH2:20][CH2:21][CH3:22]

参加物

3

反応物 2

HCID 113345124-[2-(4-Butylphenyl)ethynyl]benzaldehydeHCID 86028338Methyl [4-(aminomethyl)phenoxy]acetate acetate

生成物 1

HCID 57554567Methyl {4-[({4-[(4-butylphenyl)ethynyl]benzyl}amino)methyl]phenoxy}acetate

実験手順

The titled compound was prepared following the procedure A using methyl [4-(aminomethyl)phenoxy]acetate acetate and 4-[(4-butylphenyl)ethynyl]benzaldehyde as a pale yellow oil (36%). 1H NMR (CDCl3, 300 MHz) δ 7.46 (d, J=8.1 Hz, 2H), 7.42 (d, J=8.3 Hz, 2H), 7.29 (d, J=8.3 Hz, 2H), 7.25 (d, J=8.7 Hz, 2H), 7.13 (d, J=8.3 Hz, 2H), 6.86 (d, J=8.7 Hz, 2H), 4.60 (s, 2H), 3.79 (s, 3H), 3.78 (s, 2H), 3.72 (s, 2H), 2.59 (t, J=7.7 Hz, 2H), 1.58 (m, 2H), 1.34 (m, 2H), 0.91 (t, J=7.2 Hz, 3H). M+ (ESI): 442.3. HPLC, Rt: 4.17 min (Purity: 94.9%).

出典と根拠

ORDレコード
ord-0703250504f14115ada6198f62d12d8f
出典データセット
uspto-grants-2009_09
特許番号
US07589232B2

関連ノート

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