4-Aminotetrahydropyran → HCID 57840941、化合物
反応式
[C:1]([O:5][C:6]([N:8]1[C:12]2[C:13]([Cl:20])=[N:14][CH:15]=[C:16]([C:17](O)=[O:18])[C:11]=2[C:10]([CH3:21])=[CH:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[O:22]1[CH2:27][CH2:26][CH:25]([NH2:28])[CH2:24][CH2:23]1>>[C:1]([O:5][C:6]([N:8]1[C:12]2=[C:13]([Cl:20])[N:14]=[CH:15][C:16]([C:17](=[O:18])[NH:28][CH:25]3[CH2:26][CH2:27][O:22][CH2:23][CH2:24]3)=[C:11]2[C:10]([CH3:21])=[CH:9]1)=[O:7])([CH3:2])([CH3:4])[CH3:3]参加物
3
実験手順
Prepared in a similar manner to Example 11 (b) from 7-chloro-3-methyl-pyrrolo[2,3-c]pyridine-1,4-dicarboxylic acid 1-tert-butyl ester and using tetrahydro-pyran-4-ylamine (195 mg) instead of morpholine. The title compound was further purified by trituration with ether/isohexane to give an off-white solid (324 mg).
後処理
- customThe title compound was further purified by trituration with ether/isohexane
出典と根拠
- ORDレコード
- ord-1a5e7d9ede3f4538b3b93ff3a984b4f2
- 出典データセット
- uspto-grants-2009_09