Methanol → HCID 68866778、化合物
反応式
C(OC([N:8]1[C:12]2=[C:13]([Cl:24])[N:14]=[CH:15][C:16]([C:17](=[O:23])[NH:18][CH2:19][CH:20]3[CH2:22][CH2:21]3)=[C:11]2[C:10]([CH3:25])=[CH:9]1)=O)(C)(C)C.[CH3:26][OH:27]>>[ClH:24].[CH:20]1([CH2:19][NH:18][C:17]([C:16]2[C:11]3[C:10]([CH3:25])=[CH:9][NH:8][C:12]=3[C:13]([N:8]3[CH2:9][CH2:10][O:27][CH2:26][CH2:12]3)=[N:14][CH:15]=2)=[O:23])[CH2:21][CH2:22]1参加物
3
実験手順
Prepared in a similar manner to Example 11 (c) from 7-chloro-4-(cyclopropylmethyl-carbamoyl)-3-methyl-pyrrolo[2,3-c]pyridine-1-carboxylic acid tert-butyl ester. The solid mass was dissolved in the minimum of methanol and absorbed onto silica gel. The residue was purified by Biotage chromatography as described in Example 6 afford the title compound (14 mg).
後処理
- customabsorbed onto silica gel
- customThe residue was purified by Biotage chromatography
出典と根拠
- ORDレコード
- ord-93f1e5581d904766b6fc5852ea9730b6
- 出典データセット
- uspto-grants-2009_09