2-Methyl-2-propanesulfonyl chloride → HCID 53492360、化合物

HRID 73386

反応式

HRID 73386 の反応式
[F:1][C:2]1[C:7]([F:8])=[C:6]([NH:9][C:10]2[CH:15]=[CH:14][C:13]([I:16])=[CH:12][C:11]=2[F:17])[C:5]([NH2:18])=[CH:4][CH:3]=1.[CH3:19][C:20]([S:23](Cl)(=[O:25])=[O:24])([CH3:22])[CH3:21]>>[F:8][C:7]1[C:6]([NH:9][C:10]2[CH:15]=[CH:14][C:13]([I:16])=[CH:12][C:11]=2[F:17])=[C:5]([NH:18][S:23]([C:20]([CH3:22])([CH3:21])[CH3:19])(=[O:25])=[O:24])[CH:4]=[CH:3][C:2]=1[F:1]

参加物

3

反応物 2

HCID 125038432-Methyl-2-propanesulfonyl chlorideHCID 593863065,6-difluoro-N1-(2-fluoro-4-iodophenyl)benzene-1,2-diamine

生成物 1

HCID 53492360HCID 53492360、化合物

実験手順

According to the general procedure B, 5,6-difluoro-N1-(2-fluoro-4-iodophenyl)benzene-1,2-diamine was reacted with 2-methylpropane-2-sulfonyl chloride (synthesized according to the literature procedure) to obtain the desired product. 1H NMR (300 MHz, CDCl3): δ 7.50 (m, 1H), 7.43 (dd, J=1.8 & 10.5 Hz, 1H), 7.28 (br s, 1H), 7.10 (dd, J=9.0 & 17.7 Hz, 1H), 6.48 (br s, D2O exchangeable, 1H), 6.19 (t, J=7.8 & 9.6 Hz, 1H), 5.58 (br s, D2O exchangeable, 1H), 1.39 (s, 9H); m/z=383 [M−1]−.

後処理

  1. customsynthesized

出典と根拠

ORDレコード
ord-dd5ca2e65d15400d9dd4f072fade6b6f
出典データセット
uspto-grants-2014_09
特許番号
US08829052B2

関連ノート

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