tert-butyl N-tert-butoxycarbonyl-4,4-dimethylproline → (S)-4,4-dimethylpyrrolidine-2-carboxylic acid

反応式

C([C@@:5]1([C:19]([OH:21])=[O:20])[CH2:9][C:8]([CH3:11])([CH3:10])[CH2:7][N:6]1C(OC(C)(C)C)=O)(C)(C)C>ClCCl>[CH3:10][C:8]1([CH3:11])[CH2:7][NH:6][C@H:5]([C:19]([OH:21])=[O:20])[CH2:9]1

参加物

実験手順

A solution of tert-butyl N-tert-butoxycarbonyl-4,4-dimethylproline in dichloromethane (5 mL) and trifluoroacetic (5 mL) was stirred at room temperature for five hours. The solution was concentrated, dried under high vacuum and taken to the next step without further purification.

後処理

concentrationThe solution was concentrated
customdried under high vacuum
customtaken to the next step without further purification

出典と根拠

ORDレコード: ord-4f3358791a2444a5ab857605c23461e2
出典データセット: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07592316B2

反応ノート

読み込み中…

参加物

反応物 1

HCID 67158944tert-butyl N-tert-butoxycarbonyl-4,4-dimethylproline

生成物 1

HCID 46907953(S)-4,4-dimethylpyrrolidine-2-carboxylic acid

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

後処理

concentrationThe solution was concentrated
customdried under high vacuum
customtaken to the next step without further purification

出典と根拠

ORDレコード: ord-4f3358791a2444a5ab857605c23461e2
出典データセット: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07592316B2

反応ノート

読み込み中…