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1,1'-Carbonyldiimidazole → 4,6,7-Trifluoro-1-(2-Fluoro-4-iodo-phenyl)-1,3-dihydrobenzoimidazole-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| 反応物 | 2,3,5-trifluoro-N-(2-fluoro-4-iodophenyl)-6-nitroaniline | HCID 57430072 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 4,6,7-Trifluoro-1-(2-Fluoro-4-iodo-phenyl)-1,3-dihydrobenzoimidazole-2-one | HCID 59386379 | 65.85% |
反応手順
To the stirred solution of 3,4,6-trifluoro-N2-(2-Fluoro-4-iodo-phenyl)-benzene-1,2-diamine 3 (0.285 gm, 0.74 mmol) in CH2Cl2 (2 ml), 1,1′-carbonyldiimidazole (0.125 gm, 0.75 mmol) was added. This reaction mixture was kept stirring at room temperature for 16 hours when product precipitated out. The white solid was filtered and used further without any purification. (0.2 gm, yield: 65.85%): m/z=407 [M−1]−.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08829052B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-114df5eb246b43a98c041b01863df646 |
| 出典メモ | uspto-grants-2014_09 |