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Ammonia → 5-(Benzyloxy)-2-(hydroxymethyl)-1,4-dihydropyridin-4-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonia | HCID 222 | — |
| 反応物 | Kojic Acid | HCID 3840 | — |
| 反応物 | 5-(benzyloxy)-2-(hydroxymethyl)-4H-pyran-4-one | HCID 901598 | — |
| 反応物 | Guaiacylglycerol-beta-guaiacyl ether | HCID 6424189 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 5-(Benzyloxy)-2-(hydroxymethyl)-1,4-dihydropyridin-4-one | HCID 2801564 | — |
反応手順
A mixture of 5-benzyloxy-2-hydroxymethyl-4-pyrone (prepared from Kojic acid by the method of D. Erol, J. Med. Chem., 1994, 29, 893) (9.7 g, 40 mmol), concentrated aqueous (880) ammonia (100 mL), and ethanol (20 mL) was heated to reflux overnight. The mixture was allowed to cool to room temperature then filtered. The resultant solid was washed with ether and dried in vacuo (5.9 g); MS (APCI+) m/z 232 (MH+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07592334B2 |
| 出典データセット | uspto-grants-2009_09 |
| ORD ID | ord-c92892ff1c6b426a904d34b8fec3cc2f |
| 出典メモ | uspto-grants-2009_09 |