Acetone → HCID 68815972、化合物

HRID 734322ノート

反応式

HRID 734322 の反応式
[CH:1]([N:4]1[CH2:10][CH2:9][CH2:8][N:7]([C:11]([CH:13]2[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]2)=[O:12])[CH2:6][CH2:5]1)([CH3:3])[CH3:2].[CH3:19][C:20]([CH3:22])=[O:21].[C:23](O[BH-](OC(=O)C)OC(=O)C)(=[O:25])C.[Na+].[CH2:37](Cl)Cl>>[CH:1]([N:4]1[CH2:10][CH2:9][CH2:8][N:7]([C:11]([CH:13]2[CH2:14][CH2:15][N:16]([C:23]([O:21][C:20]([CH3:37])([CH3:22])[CH3:19])=[O:25])[CH2:17][CH2:18]2)=[O:12])[CH2:6][CH2:5]1)([CH3:3])[CH3:2]

参加物

5

反応物 4

HCID 180AcetoneHCID 6344DichloromethaneHCID 5049666Sodium triacetoxyborohydrideHCID 11550595AG-H-20408

生成物 1

HCID 68815972HCID 68815972、化合物

実験手順

The product of D8, Step 2 (2.0 g) was dissolved in DCM (50 ml) and acetone (0.94 ml) added and the mixture stirred for 5 min. Sodium triacetoxyborohydride (2.7 g) was then added and the reaction stirred at rt for 1.5 h. The reaction mixture was then washed with saturated potassium carbonate solution (50 ml), sodium hydrogen carbonate solution (3×50 ml) and brine (50 ml). The organic layer was dried (MgSO4) and evaporated to give the subtitled compound as a white solid (1.50 g).

後処理

  1. stirringthe reaction stirred at rt for 1.5 h
  2. washThe reaction mixture was then washed with saturated potassium carbonate solution (50 ml), sodium hydrogen carbonate solution (3×50 ml) and brine (50 ml)
  3. dry with materialThe organic layer was dried (MgSO4)
  4. customevaporated

出典と根拠

ORDレコード
ord-4355d4a6639e41e09905cb4ab546c64d
出典データセット
uspto-grants-2009_09
特許番号
US07592347B2

反応ノート

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