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Cesium carbonate → 1-[3-(benzyloxy)benzyl]-2-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1h-imidazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Cesium carbonate | HCID 10796 | — |
| 反応物 | 3-Benzyloxybenzyl bromide | HCID 1502047 | — |
| 反応物 | Demiditraz | HCID 24738933 | — |
| 溶媒 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 生成物 | 1-[3-(benzyloxy)benzyl]-2-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1h-imidazole | HCID 57718416 | — |
反応手順
To a mixture of the compound of Example 58 (90 mg, 0.45 mmol) and caesium carbonate (244 mg, 0.75 mmol) in 1-methyl-2-pyrrolidinone (1 ml) was added 1-(benzyloxy)-3-(bromomethyl)benzene (139 mg, 0.50 mmol). The reaction mixture was stirred at room temperature for 48 h and then filtered through a Whatman PTFE filter tube (5 μm).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07592362B2 |
| 出典データセット | uspto-grants-2009_09 |
| ORD ID | ord-2e13b1e069554b41bf6b9d939244af14 |
| 出典メモ | uspto-grants-2009_09 |