Water → 1-(2-Bromo-3,5,6-trimethylphenyl)ethanone
反応式
[Br:1][C:2]1[CH:7]=[C:6]([CH3:8])[C:5]([CH3:9])=[CH:4][C:3]=1[CH3:10].[C:11](Cl)(=[O:13])[CH3:12].[Cl-].[Al+3].[Cl-].[Cl-].O>ClCCl>[Br:1][C:2]1[C:3]([CH3:10])=[CH:4][C:5]([CH3:9])=[C:6]([CH3:8])[C:7]=1[C:11](=[O:13])[CH3:12]参加物
6
実験手順
To a mixture of 1-bromo-2,4,5-trimethylbenzene (5.0 g, 25.0 mmol) and acetyl chloride (2.45 ml, 34.5 mmol) in dichloromethane (50 ml) was added aluminium chloride (4.42 g, 33.1 mmol) in dichloromethane (50 ml) and the reaction mixture was stirred at room temperature for 18 h. The mixture was poured into water and the two layers were separated. The organic phase was washed with saturated aqueous sodium hydrogen carbonate solution, dried (MgSO4) and filtered through silica. The filtrate was concentrated in vacuo to give the title compound (5.50 g).
後処理
- customthe two layers were separated
- washThe organic phase was washed with saturated aqueous sodium hydrogen carbonate solution
- dry with materialdried (MgSO4)
- filtrationfiltered through silica
- concentrationThe filtrate was concentrated in vacuo
出典と根拠
- ORDレコード
- ord-de994c566245469aa291f3d09cf5d79b
- 出典データセット
- uspto-grants-2009_09
- 特許番号
- US07592362B2
反応ノート
読み込み中…