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Potassium Carbonate → Ethyl 2-(3-(4-(trifluoromethyl)benzyloxy)phenyl)acetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 1-(Bromomethyl)-4-(trifluoromethyl)benzene | HCID 123062 | — |
| 反応物 | Ethyl (3-Hydroxyphenyl)acetate | HCID 572437 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | Ethyl 2-(3-(4-(trifluoromethyl)benzyloxy)phenyl)acetate | HCID 11974618 | — |
反応手順
To a stirred solution of Ethyl 2-(3-hydroxyphenyl)acetate (7.3 g, 30.5 mmol) in DMF (20 ml) was added potassium carbonate (5.47 g, 39.6 mmol) at room temperature followed by drop wise addition of 4-Trifluoromethylbenzyl bromide (6.04 g, 33.6 mmol). The reaction mixture was stirred for 12 hours and taken in ethyl acetate, washed with water (2×), brine, dried over Na2SO4, filtered, concentrated and purified by flash chromatography on a silica gel column (hex:ether 5:1) to give the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08829058B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-4d3e1724736d422eb437a7f180dce3b5 |
| 出典メモ | uspto-grants-2014_09 |