Hydrochloric Acid → 6-Fluoro-2-methyl-5-(1-piperazinyl)quinoline

HRID 734548ノート

反応式

HRID 734548 の反応式
Cl.CC([CH:6]1[CH2:11][N:10]([C:12]2[C:21]([F:22])=[CH:20][CH:19]=[C:18]3[C:13]=2[CH:14]=[CH:15][C:16]([CH3:23])=[N:17]3)[CH2:9][CH2:8][N:7]1C([O-])=O)(C)C>O1CCOCC1>[F:22][C:21]1[C:12]([N:10]2[CH2:9][CH2:8][NH:7][CH2:6][CH2:11]2)=[C:13]2[C:18](=[CH:19][CH:20]=1)[N:17]=[C:16]([CH3:23])[CH:15]=[CH:14]2

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 866084411,1-Dimethylethyl-4-(6-fluoro-2-methyl-5-quinolinyl)-1-piperazinecarboxylate

生成物 1

HCID 574443146-Fluoro-2-methyl-5-(1-piperazinyl)quinoline収率 156.2%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒2 回

実験手順

A solution of hydrogen chloride in dioxane (4M, 4 mL) was added to a solution of 1,1-dimethylethyl-4-(6-fluoro-2-methyl-5-quinolinyl)-1-piperazinecarboxylate (0.178 g) in dioxane (4 mL) at 0° C. The resulting mixture was warmed to room temperature and stirred for 15 h. The mixture was concentrated in vacuo and partitioned between aqueous sodium hydroxide solution and DCM. The combined organic phases were washed with brine, dried over sodium sulfate and concentrated to afford the title compound (198 mg, 100% yield).

後処理

  1. concentrationThe mixture was concentrated in vacuo
  2. custompartitioned between aqueous sodium hydroxide solution and DCM
  3. washThe combined organic phases were washed with brine
  4. dry with materialdried over sodium sulfate
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-096c26b9d05047408e23a320e8b9531b
出典データセット
uspto-grants-2009_09
特許番号
US07592346B2

反応ノート

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