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Triphenylphosphine → Ethyl 3-(2,6-dimethylbenzyloxy)phenylacetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triphenylphosphine | HCID 11776 | — |
| 反応物 | Diisopropyl diazene-1,2-dicarboxylate | HCID 75555 | — |
| 反応物 | (2,6-Dimethylphenyl)methanol | HCID 186748 | — |
| 反応物 | Ethyl (3-Hydroxyphenyl)acetate | HCID 572437 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | Ethyl 3-(2,6-dimethylbenzyloxy)phenylacetate | HCID 66875723 | — |
反応手順
A solution of 2,6-Dimethylbenzyl alcohol (5.25 g, 38.6 mmol) and diisopropyl azodicarboxylate (DIAD, 8.49 g, 42 mmol) in THF (30 ml) was added drop wise to a solution of Ethyl 3-hydroxyphenylacetate (6.66 g, 37 mmol) and triphenylphosphine (11 g, 42 mmol) in THF (100 ml). The reaction mixture was stirred at room temperature for 4 hours, diluted with ether and washed with water and brine. The organic layer was dried over Na2SO4, filtered, concentrated, and purified by flash chromatography on a silica gel column (hex:ethyl acetate 4:1) to give the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08829058B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-7f54110c036a4245bf7e46d6ba4e12b0 |
| 出典メモ | uspto-grants-2014_09 |