Triphenylphosphine → Ethyl 2-(2-(2,6-dimethylbenzyloxy)phenyl)acetate

関与物質

役割	名称	HCID	仕込み量
反応物	Triphenylphosphine	HCID 11776	—
反応物	Diisopropyl diazene-1,2-dicarboxylate	HCID 75555	—
反応物	(2,6-Dimethylphenyl)methanol	HCID 186748	—
反応物	2-(2-Hydroxyphenyl)acetic acid ethyl ester	HCID 521075	—
溶媒	Diethyl Ether	HCID 3283	—
溶媒	Tetrahydrofuran	HCID 8028	—
生成物	Ethyl 2-(2-(2,6-dimethylbenzyloxy)phenyl)acetate	HCID 66875211	—

反応手順

A solution of 2,6-Dimethylbenzyl alcohol (2.72 g, 19.9 mmol) and diisopropyl azodicarboxylate (DIAD, 3.67 g, 18.2 mmol) in THF (30 ml) was added drop wise to a solution of Ethyl 2-(2-hydroxyphenyl)acetate (3 g, 16.6 mmol) and triphenylphosphine (4.76 g, 18.2 mmol) in THF (80 ml). The reaction mixture was stirred at room temperature for 6 hours, diluted with ether and washed with water and brine. The organic layer was dried over Na2SO4, filtered, concentrated, and purified by flash chromatography on a silica gel column (hex:ethyl acetate 4:1) to give the title compound.

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US08829058B2
出典データセット	uspto-grants-2014_09
ORD ID	ord-7c09c85c35414845bd80800128d5b651
出典メモ	uspto-grants-2014_09