化工社化工社 化学情報印刷レポート · 研究参考用
Methanol → Methyl 4-chloro-3-sulfamoylbenzoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | 4-Chloro-3-sulfamoylbenzoic acid | HCID 14568 | — |
| 触媒 | Sulfuric Acid | HCID 1118 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | Methyl 4-chloro-3-sulfamoylbenzoate | HCID 4277179 | 95% |
反応手順
3-(Aminosulfonyl)-4-chlorobenzoic acid (943 mg, 4.0 mmol) was heated at 70° C. in CH3OH (10 mL) with 3 drops of concentrated sulfuric acid for 34 hours. The reaction mixture was diluted with EtOAc (20 mL), washed with water, brine, and dried (Na2SO4). The solvent was evaporated to afford the product (950 mg, 95%) as a white solid. MS (ES+) m/z 250 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07592357B2 |
| 出典データセット | uspto-grants-2009_09 |
| ORD ID | ord-2ba078ff6fe9468996bc53adcbb229cd |
| 出典メモ | uspto-grants-2009_09 |