化工社化工社 化学情報印刷レポート · 研究参考用
Methanol → Benzoic acid, 3-(aminosulfonyl)-, methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | 3-Sulfamoylbenzoic acid | HCID 229352 | — |
| 触媒 | Sulfuric Acid | HCID 1118 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | Benzoic acid, 3-(aminosulfonyl)-, methyl ester | HCID 108836 | 98% |
反応手順
3-(Aminosulfonyl)benzoic acid (603 mg, 3.0 mmol) was heated at 80° C. in CH3OH (3 mL) with 3 drops of concentrated sulfuric acid for 60 hours. The reaction mixture was diluted with EtOAc (20 mL), washed with water, brine, and dried (Na2SO4). The solvent was evaporated to afford the product (630 mg, 98%) as a white solid. MS (ES+) m/z 216 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07592357B2 |
| 出典データセット | uspto-grants-2009_09 |
| ORD ID | ord-a4b72a81d93e43e8aa724688c2f86acf |
| 出典メモ | uspto-grants-2009_09 |