戻る
化工社化工社 化学情報印刷レポート · 研究参考用
HRID 734804作成日：2026年10月25日

BROMINE CHLORIDE (BrCl) → 2-{2-Bromo-4-[5-(4-chlorophenyl)-3-fluoropyridin-2-ylethynyl]phenoxy}ethanol

https://huagongshe.com/reaction/734804

反応式

関与物質

役割名称HCID仕込み量
反応物BROMINE CHLORIDE (BrCl)HCID 61697—
反応物5-(4-Chlorophenyl)-2-ethynyl-3-fluoropyridineHCID 60055416—
反応物2-(2-Bromo-4-iodophenoxy)ethanolHCID 69062443—
生成物2-{2-Bromo-4-[5-(4-chlorophenyl)-3-fluoropyridin-2-ylethynyl]phenoxy}ethanolHCID 69064880—

反応手順

The product was prepared analogously to Example 7.1e starting from 2-(2-bromo-4-iodophenoxy)ethanol and 5-(4-chlorophenyl)-2-ethynyl-3-fluoropyridine. Yield: 1.60 g (82% of theoretical); C21H14BrClFNO2 (M=446.697); calc.: molpeak (M+H)+: 446/448/450 (BrCl); found: molpeak (M+H)+: 446/448/450 (BrCl); HPLC-MS: 6.38 minutes (method B).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07592358B2
出典データセットuspto-grants-2009_09
ORD IDord-f24aba2a1790406dbb8c819b2ab39e14
出典メモuspto-grants-2009_09