1-(2-Chloroethyl)pyrrolidine hydrochloride → 1-[2-(4-Bromo-2-methoxyphenoxy)ethyl]pyrrolidine
反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[C:4]([O:9][CH3:10])[CH:3]=1.Cl.Cl[CH2:13][CH2:14][N:15]1[CH2:19][CH2:18][CH2:17][CH2:16]1>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:13][CH2:14][N:15]2[CH2:19][CH2:18][CH2:17][CH2:16]2)=[C:4]([O:9][CH3:10])[CH:3]=1参加物
3
実験手順
The product was obtained analogously to Example 24.1a starting from 4-bromo-2-methoxyphenol and 1-(2-chloroethyl)pyrrolidine hydrochloride. Yield: 3.96 g (45% of theoretical); C13H19BrNO2 (M=300.192); calc.: molpeak (M+H)+: 300/302 (Br); found: molpeak (M+H)+: 300/302 (Br); HPLC-MS: 4.67 minutes (method A).
後処理
- customThe product was obtained analogously to Example 24.1a
- custom4.67 minutes (method A)
出典と根拠
- ORDレコード
- ord-ab5c9fbf59724ae586c30cd0eb674a38
- 出典データセット
- uspto-grants-2009_09
- 特許番号
- US07592358B2
反応ノート
読み込み中…