2-(4-Chloro-2-methylphenyl)-5-trimethylsilanylethynylpyrazine → 2-(4-Chloro-2-methylphenyl)-5-ethynylpyrazine
反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[N:12][C:11]([C:14]#[C:15][Si](C)(C)C)=[CH:10][N:9]=2)=[C:4]([CH3:20])[CH:3]=1>CCOC(C)=O>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[N:12][C:11]([C:14]#[CH:15])=[CH:10][N:9]=2)=[C:4]([CH3:20])[CH:3]=1参加物
3
実験手順
The product was prepared analogously to Example 1.1c from 700 mg (2.33 mmol) of 2-(4-chloro-2-methylphenyl)-5-trimethylsilanylethynylpyrazine (40 minutes at RT, DCM as solvent). Yield: 200 mg (38% of theoretical); C13H9ClN2 (M=228.677); calc.: molpeak (M+H)+:229/231 (Cl); found: molpeak (M+H)+:229/231 (Cl); Rf value: 0.2 (silica gel, PE/EtOAc 9:1).
出典と根拠
- ORDレコード
- ord-ced1ef60cc2c40f0ad842506ac69ad27
- 出典データセット
- uspto-grants-2009_09
- 特許番号
- US07592358B2
反応ノート
読み込み中…