(tert-Butyldimethylsilyl)acetylene → 5-Bromo-2-[(tert-butyldimethylsilanyl)ethynyl]-3-fluoropyridine
反応式
Br[C:2]1[C:7]([F:8])=[CH:6][C:5]([Br:9])=[CH:4][N:3]=1.[C:10]([Si:14]([C:17]#[CH:18])([CH3:16])[CH3:15])([CH3:13])([CH3:12])[CH3:11]>>[Br:9][C:5]1[CH:6]=[C:7]([F:8])[C:2]([C:18]#[C:17][Si:14]([C:10]([CH3:13])([CH3:12])[CH3:11])([CH3:16])[CH3:15])=[N:3][CH:4]=1参加物
3
実験手順
The product was prepared analogously to Example 48.1c from 23.4 g (92.0 mmol) of 2,5-dibromo-3-fluoropyridine and 17.5 mL (92.0 mmol) of tert-butylethynyldimethylsilane (with triethylamine as base and PdCl2(PPh3)2 as catalyst). Yield: 23.3 g (81% of theoretical); C13H17BrFNSi (M=314.269); calc.: molpeak (M+H)+:314/316 (Br); found: molpeak (M+H)+:314/316 (Br).
出典と根拠
- ORDレコード
- ord-e2267c8d0bd34b59952a6f475fca47d8
- 出典データセット
- uspto-grants-2009_09
- 特許番号
- US07592358B2
反応ノート
読み込み中…