関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Diisopropyl Ether | HCID 7914 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Pyrrolidine | HCID 31268 | — |
| 反応物 | 2-(Chloromethyl)-5-nitro-1,3-benzoxazole | HCID 2764189 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 5-Nitro-2-pyrrolidin-1-ylmethylbenzoxazole | HCID 59766992 | — |
反応手順
A reaction mixture of 3 g (14.11 mmol) of 2-chloromethyl-5-nitrobenzoxazole, 1.5 mL (17.97 mmol) of pyrrolidine, and 3.9 g (28.22 mmol) of potassium carbonate in 30 mL of DMF is stirred for 4 hours at 50° C. Then the reaction mixture is diluted with water and covered with diisopropyl ether, The precipitated yellow solid is suction filtered, washed again, and dried in the circulating air dryer at 60° C. Yield: 1.8 g (52% of theory); C12H13N3O3 (M=247.25); calc.: molecular ion peak (M+H)+: 248; found: molecular ion peak (M+H)+: 248; Rf value: 0.4 (silica gel, dichloromethane/ethanol (20:1)).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07592373B2 |
|---|
| 出典データセット | uspto-grants-2009_09 |
|---|
| ORD ID | ord-652e8ce8327f40859f9e5f8de2b56507 |
|---|
| 出典メモ | uspto-grants-2009_09 |
|---|
