4-Methylpiperidine → HCID 68818181、化合物
反応式
Br[CH2:2][CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][C:6]=1[Cl:14].[CH3:15][CH:16]1[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1>ClCCl>[Cl:14][C:6]1[CH:7]=[C:8]([N+:11]([O-:13])=[O:12])[CH:9]=[CH:10][C:5]=1[O:4][CH2:3][CH2:2][N:19]1[CH2:20][CH2:21][CH:16]([CH3:15])[CH2:17][CH2:18]1参加物
4
実験手順
A reaction mixture of 7.8 g (27.81 mmol) of 1-(2-bromoethoxy)-2-chloro-4-nitrobenzene and 10.14 mL (84 mmol) of 4-methylpiperidine in 100 mL of dichloromethane is stirred for 18 hours at ambient temperature. Then the solution is purified by column chromatography on 400 g of Alox act. II-III (eluant: dichloromethane/methanol (49:1)). Yield: 6.9 g (83% of theory); C14H19ClN2O3 (M=298.77); calc.: molecular ion peak (M+H)+: 209/301; found: molecular ion peak (M+H)+: 209/301; Rf value: 0.48 (Alox, petroleum ether/ethyl acetate (3:1)).