Dichloromethane methanol → 2-chloro-N'-[2-(4-methylpiperidin-1-yl)ethyl]benzene-1,4-diamine

反応式

Cl[C:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[CH:5]=[CH:4][C:3]=1[NH:11][CH2:12][CH2:13][N:14]1[CH2:19][CH2:18][CH:17]([CH3:20])[CH2:16][CH2:15]1.[Cl:21]CCl.CO>>[Cl:21][C:5]1[CH:4]=[C:3]([NH:11][CH2:12][CH2:13][N:14]2[CH2:19][CH2:18][CH:17]([CH3:20])[CH2:16][CH2:15]2)[CH:2]=[CH:7][C:6]=1[NH2:8]

参加物

反応物 2

HCID 21226129Dichloromethane methanol

HCID 55828782(2-Chloro-4-nitrophenyl)-[2-(4-methylpiperidin-1-yl)ethyl]amine

生成物 1

HCID 688178732-chloro-N'-[2-(4-methylpiperidin-1-yl)ethyl]benzene-1,4-diamine

実験手順

Prepared analogously to Example 3.1.b. from (2-chloro-4-nitrophenyl)-[2-(4-methylpiperidin-1-yl)ethyl]amine. Yield: 7 g (89.3% of theory); C14H22ClN3 (M=267.80); calc.: molecular ion peak (M+H)+: 268/270; found: molecular ion peak (M+H)+: 268/270; Rf value: 0.6 (Alox, dichloromethane/methanol (49:1)).

後処理

customPrepared analogously to Example 3.1.b

出典と根拠

ORDレコード: ord-5ef646f006e84f2e8b645677e44c9009
出典データセット: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07592373B2

反応ノート

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