Benzyl Bromide → 2-benzyl-3-(4-methoxy-phenyl)-7-trifluoromethyl-2H-indazole

HRID 735407ノート

反応式

HRID 735407 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:17]3[C:12](=[C:13]([C:18]([F:21])([F:20])[F:19])[CH:14]=[CH:15][CH:16]=3)[NH:11][N:10]=2)=[CH:5][CH:4]=1.[CH2:22](Br)[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1.C(OCC)(=O)C>CN(C=O)C>[CH2:22]([N:10]1[C:9]([C:6]2[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:8][CH:7]=2)=[C:17]2[C:12]([C:13]([C:18]([F:21])([F:19])[F:20])=[CH:14][CH:15]=[CH:16]2)=[N:11]1)[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1

参加物

5

反応物 3

HCID 7498Benzyl BromideHCID 8857Ethyl AcetateHCID 178489134HCID 178489134、化合物

生成物 1

HCID 115960792-benzyl-3-(4-methoxy-phenyl)-7-trifluoromethyl-2H-indazole収率 79.8%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
120 °C

実験手順

To a solution of 3-(4-methoxy-phenyl)-7-trifluoromethyl-1H-indazole (59 mg, 0.2 mmol) in 0.5 ml DMF were added 72 μl of benzyl bromide (0.6 mmol). The reaction mixture was heated overnight at 120° C. After cooling to room temperature, ethyl acetate was added and the solution was washed three times with brine. The organic layer was dried over MgSO4 and concentrated. Column chromatography (n-heptane/ethyl acetate, 70:30 as eluent) afforded 61 mg of pure product.

後処理

  1. temperatureAfter cooling to room temperature
  2. washthe solution was washed three times with brine
  3. dry with materialThe organic layer was dried over MgSO4
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-6122a12572e74474b1d6b2e253ddce98
出典データセット
uspto-grants-2009_09
特許番号
US07592363B2

反応ノート

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