HCID 57842902、化合物 → HCID 57842775、化合物
反応式
[C:1]([O:5][C:6]([N:8]([C:50]([O:52][C:53]([CH3:56])([CH3:55])[CH3:54])=[O:51])[C:9]1[C:18]2[C:13](=[CH:14][C:15]([NH:19][CH:20]([C:24]3[CH:29]=[CH:28][C:27]([CH2:30][CH2:31][N:32]([CH3:49])[C:33]([NH:35][C:36]4[CH:41]=[CH:40][C:39]([S:42]([CH2:45][CH3:46])(=[O:44])=[O:43])=[C:38]([C:47]#[N:48])[CH:37]=4)=[O:34])=[CH:26][CH:25]=3)[C:21]([OH:23])=[O:22])=[CH:16][CH:17]=2)[CH:12]=[CH:11][N:10]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2]>CO.[Ni]>[NH2:48][CH2:47][C:38]1[CH:37]=[C:36]([NH:35][C:33](=[O:34])[N:32]([CH2:31][CH2:30][C:27]2[CH:28]=[CH:29][C:24]([CH:20]([NH:19][C:15]3[CH:14]=[C:13]4[C:18](=[CH:17][CH:16]=3)[C:9]([N:8]([C:6]([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[O:7])[C:50]([O:52][C:53]([CH3:54])([CH3:55])[CH3:56])=[O:51])=[N:10][CH:11]=[CH:12]4)[C:21]([OH:23])=[O:22])=[CH:25][CH:26]=2)[CH3:49])[CH:41]=[CH:40][C:39]=1[S:42]([CH2:45][CH3:46])(=[O:44])=[O:43]参加物
4
実験手順
A solution of 25D (460 mg, 0.59 mmol) in MeOH (50 mL) with catalytic Raney Ni was stirred under an atmosphere of H2 (70 psi) for 20 h. The reaction mixture was filtered through Celite and concentrated to give 25E (340 mg, 73%) as a yellow oil. MS (ESI) m/z 790.95 (M+H)+.