Hydroxylamine → N'-hydroxydodecanimidamide

HRID 735827

反応式

HRID 735827 の反応式
[CH2:1]([C:12]#[N:13])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH3:11].[NH2:14][OH:15]>CCO>[OH:15][NH:14][C:12](=[NH:13])[CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH3:11]

参加物

4

反応物 2

HCID 787HydroxylamineHCID 17092Dodecanenitrile

生成物 1

HCID 178443266N'-hydroxydodecanimidamide収率 94%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
70 °C

実験手順

To a solution of undecyl cyanide (1.810 g, 9.98 mmol) in EtOH (20 mL) was added a 50% aqueous solution of hydroxylamine (1 mL) and the resulting reaction mixture was stirred at 70° C. for 48 h. The solvents were evaporated and the resulting white solid was dissolved in EtOAc (100 mL) and washed with H2O (2×20 mL), dried over MgSO4, filtered and the solvents evaporated under vacuum to give the title compound as a white solid (2.001 g, 94%). 1H NMR (CDCl3, 300 MHz) δ 6.21-4.99 (br s, 1H), 4.49 (br s, 2H), 2.07 (t, J=7.6 Hz, 2H), 1.55-1.40 (m, 2H), 1.34-1.09 (m, 16H), 0.81 (t, J=7.0 Hz, 3H)

後処理

  1. customthe resulting reaction mixture
  2. customThe solvents were evaporated
  3. dissolutionthe resulting white solid was dissolved in EtOAc (100 mL)
  4. washwashed with H2O (2×20 mL)
  5. dry with materialdried over MgSO4
  6. filtrationfiltered
  7. customthe solvents evaporated under vacuum

出典と根拠

ORDレコード
ord-12ccef84d5c1470393d526898f587d16
出典データセット
uspto-grants-2009_09
特許番号
US07592477B2

関連ノート

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