4-Formylbenzoic acid → 4-(3-Octyl-1,2,4-oxadiazol-5-yl)benzaldehyde

HRID 735916

反応式

HRID 735916 の反応式
[C:1]([C:4]1[CH:11]=[CH:10][C:7]([CH:8]=[O:9])=[CH:6][CH:5]=1)([OH:3])=O.O[NH:13][C:14](=[NH:23])[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22]>>[CH2:15]([C:14]1[N:13]=[C:1]([C:4]2[CH:11]=[CH:10][C:7]([CH:8]=[O:9])=[CH:6][CH:5]=2)[O:3][N:23]=1)[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22]

参加物

3

反応物 2

HCID 120884-Formylbenzoic acidHCID 5074022N'-hydroxynonanimidamide

生成物 1

HCID 865985324-(3-Octyl-1,2,4-oxadiazol-5-yl)benzaldehyde収率 34%

実験手順

The same procedure as employed in the preparation of Example 277 (step a) but using 4-carboxybenzaldehyde and N-hydroxynonanimidamide gave the title compound as a beige solid (34%). 1H NMR (CDCl3, 300 MHz) δ 10.1 (s, 1H), 8.29 (d, 2H, J=8.3 Hz), 8.03 (d, 2H, J=8.3 Hz), 2.81 (t, 2H, J=7.4 Hz), 1.86-1.75 (m, 2H), 1.46-1.21 (m, 10H), 0.87 (m, 3H). HPLC (Condition A), Rt: 5.16 min (HPLC purity: 95.4%).

後処理

  1. customThe same procedure as employed in the preparation of Example 277 (step a) but

出典と根拠

ORDレコード
ord-701c1f03980241c7ad958d767f09c87a
出典データセット
uspto-grants-2009_09
特許番号
US07592477B2

関連ノート

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