5-Tetralinylamine → N-5,6,7,8-tetrahydronaphthalen-1-yl-N-[3-(3-undecyl-1,2,4-oxadiazol-5-yl)benzyl]amine

反応式

[CH2:1]([C:12]1[N:16]=[C:15]([C:17]2[CH:18]=[C:19]([CH:22]=[CH:23][CH:24]=2)[CH:20]=O)[O:14][N:13]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH3:11].[C:25]1([NH2:35])[C:34]2[CH2:33][CH2:32][CH2:31][CH2:30][C:29]=2[CH:28]=[CH:27][CH:26]=1>>[C:25]1([NH:35][CH2:20][C:19]2[CH:22]=[CH:23][CH:24]=[C:17]([C:15]3[O:14][N:13]=[C:12]([CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH3:11])[N:16]=3)[CH:18]=2)[C:34]2[CH2:33][CH2:32][CH2:31][CH2:30][C:29]=2[CH:28]=[CH:27][CH:26]=1

参加物

反応物 2

HCID 166715-Tetralinylamine

HCID 865985383-(3-Undecyl-1,2,4-oxadiazol-5-yl)benzaldehyde

生成物 1

HCID 67186609N-5,6,7,8-tetrahydronaphthalen-1-yl-N-[3-(3-undecyl-1,2,4-oxadiazol-5-yl)benzyl]amine

実験手順

The same procedure as employed in the preparation of Example 357 (step a) but using 3-(3-undecyl-1,2,4-oxadiazol-5-yl)benzaldehyde and 5,6,7,8-tetrahydronaphthalen-1-ylamine gave the title compound as an oil. M+(LC/MS(ESI)): 460.4. HPLC (Condition A), Rt: 6.32 min (HPLC purity: 68.9%).

後処理

customThe same procedure as employed in the preparation of Example 357 (step a) but

出典と根拠

ORDレコード: ord-f5babc278ab74eb4b2eae1a9bb2612eb
出典データセット: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07592477B2

反応ノート

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