化工社化工社 化学情報印刷レポート · 研究参考用
2,6-Difluorobenzamide → 2,6-Difluorobenzene-1-carbothioamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2,6-Difluorobenzamide | HCID 87439 | — |
| 反応物 | Lawesson's reagent | HCID 87949 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 2,6-Difluorobenzene-1-carbothioamide | HCID 12683212 | 99% |
反応手順
A solution of 2, 6 difluorobenzamide (1 eq) and Lawesson's reagent (0.5 eq.) in toluene (0.2 M) was heated at 90° C. for 14 hours. Upon cooling the volatiles were removed in vacuo and purified by SiO2 chromatography (25% EtOAc/hexanes) yielding 2,6-difluorobenzothioamide as a light yellow solid (99%). LCMS (m/z): 174.1 (MH+); LC Rt=2.19 min.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08829193B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-b0b6e2c6e1cd425cb1c695a43492eb1a |
| 出典メモ | uspto-grants-2014_09 |